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A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Novel genetic associations for blood pressure jonas mols facebook via gene-alcohol interaction in up to K individuals across multiple ancestries.
PLoS Med. PMID: Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto Jonas mols facebook, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N.
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of jonas mols facebook cells. J Diabetes Invest. Circ J. Multiple Non-glycemic Genomic Loci Are Newly Associated with Blood Level of Glycated Jonas mols facebook in East Asians.
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Hepatol Int. Multi-ancestry genome-wide gene-smoking interaction study ofindividuals identifies new loci associated with serum lipids.
Genetic impacts on uric acid concentration and hyperuricemia in the Japanese population.
The fine-scale genetic structure and evolution of the Japanese population. Vascular complications and coagulation-related changes in the perioperative period in Japanese patients undergoing non-cardiac surgery. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice. Hypertens Res. Wang X, Chua HX, Chen P, Ong RT, Sim X, Zhang W, Takeuchi F, Liu X, Khor CC, Tay WT, Cheng CY, Suo C, Liu J, Aung T, Chia KS, Kooner JS, Chambers JC, Wong TY, Tai ES, Kato N, Teo YY. PMID: Deng L, Hoh B-P, Lu D, Saw W-Y, Ong R T-H, Kasturiratne A, de Silva HJ, Zilfalil BA, Kato N, Wickremasinghe AR, TeoY-Y, Xu S. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Comparison of coronary heart disease risk among four diagnostic definitions of metabolic syndrome. Nat Genet. PMID: Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H. Incidence and risk factors for non-alcoholic fatty liver disease: A 7-year follow-up study among urban, adult Sri Lankans. Ceylon Med J. Nat Commun. PMID: Kelly TN, Takeuchi F, Tabara Y, Edwards TL, Kim YJ, Chen P, Li H, Wu Y, Yang CF, Zhang Y, Gu D, Katsuya T, Ohkubo T, Gao YT, Go MJ, Teo YY, Lu L, Lee NR, Chang LC, Peng H, Zhao Q, Nakashima E, Kita Y, Shu XO, Kim NH, Tai ES, Wang Y, Adair LS, Chen CH, Zhang S, Li C, Nabika T, Umemura S, Cai Q, Cho YS, Wong TY, Zhu J, Wu JY, Gao X, Hixson JE, Cai H, Lee J, Cheng CY, Rao DC, Xiang YB, Cho MC, Han BG, Wang A, Tsai FJ, Mohlke K, Lin X, Ikram MK, Lee JY, Zheng W, Tetsuro M, Kato N, He J. PMID: 年 Suzuki T, Zeng Z, Zhao B, Wei Z, Tanabe M, Shimbo T, Kajio H, Kato N, Naruse M. Am J Hum Genet. Association of genetic variants with non-alcoholic fatty liver disease in an urban Sri Lankan community Liver Int. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci. Heterogeneous effects of association between blood pressure loci and coronary artery disease in east Asian individuals. PMID: Niriella MA, Pathmeswaran A, De Silva ST, Kasturiratna A, Perera R, Subasinghe CE, Kodisinghe K, Piyaratna C, Rishikesawan V, Dassanayaka AS, De Silva AP, Wickramasinghe R, Takeuchi F, Kato N, de Silva HJ. Investigation of Functional Genes at Homologous Loci Identified Based on Genome-wide Association Studies of Blood Lipids via High-fat Diet Intervention in Rats using an in vivo Approach. Mapping the genetic diversity of HLA haplotypes in the Japanese populations. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. J Endocrinol Invest. Int Heart J. Lean non-alcoholic fatty liver disease lean NAFLD : characteristics, metabolic outcomes and risk factors from a 7-year prospective, community cohort study from Sri Lanka. J Atheroscler Thromb. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. PMID: Niiya K, Ohara H, Isono M, Sheikh AM, Matsuo H, Fujikawa K, Isomura M, Kato N, Nabika T. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Liver Int. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Eur J Prev Cardiol. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. PMID: Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T. Insights into the genetic basis of type 2 diabetes. Characterising private and shared signatures of positive selection in 37 Asian populations. PMID: Ranawaka UK, Wijekoon CN, Pathmeswaran A, Kasturiratne A, Gunasekera D, Chackrewarthy S, Kato N, Wickremasinghe AR. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. PMID: 年 Saw W-Y, Liu X, Khor C-C, Takeuchi F, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Yamamoto K, Yokota M, Japanese Genome Variation consortium, Teo Y-Y, Kato N. Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. PMID: Kim YK, Kim Y, Hwang MY, Shimokawa K, Won S, Kato N, Tabara Y, Yokota M, Han BG, Lee JH, Kim BJ. Int Immunol. PMID: Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S. Candidate genes revisited in the genetics of hypertension and blood pressure. PMID: He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L.